ANTIPYRINE

n. A?n-ti?p'i2-ren. From dvti, against, and mp, fever-heat. Fr., antipyrine. Ger., Antipyrin. It., Sp., an- A?n(asn)- tipirina, Syn.: dimethyl oxy quin i zine. An artificial alkaloid, Cy FyaN20 = C,(H, H,,H,C0 — CH, = CCH), NCH), — first obtained by L. Knorr, of Erlangen, by boiling oxy methyl quin i zine ‘with equal parts of methyl alcohol and methyl iodide; a white erystalline powder, melting at 113° C., soluble in water, in alcohol, and in chloroform, but soluble with difficulty in ether, and of a slightly bitter taste. It was introduced into medicine as an antipyretic by Filehne in 1881, and, given in doses of from 15 to 75 grains, it is one of the most efficient drugs for reducing the temperature. Its use is sometimes followed by profuse sweating aud, le often, by an erythematous rash accompanied with great itching. In poisonous doses it produces paralysis of the heart. Four and five-per-cent. solutions of it have been used locally as a hemostatic, |Filehne, “ Ztschr, f. klin. Med.,” vii, p. 6 (B); Yvon, “Progr. méd.,” Jan. 17, 1885, p. 50; G. L. Peabody and E. G. Janeway, “ N. Y. Med. Jour..” Jan. 24, 1885. p. 107; E. Casetti, “ Raccoglitore med.,” Aug., 1885; “N.Y. Med. Jour.,”” Feb. 6, 1886, p. 172.]