Exacerbate

Chamber's Twientieth Century Dictionary · 1908 · p. 37
egz-as′ėr-bāt, or eks-, v.t. to embitter: to provoke: to render more violent or severe, as a disease.— ns. Exacerbā′tion , Exacerbes′cence , increase of irritation or violence, esp. the increase of a fever or disease: embitterment. [L. exacerbāre , -ātum — ex , and acerbāre , from acerb us , bitter.]
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