DISEASE

n. Di2z-ez'. Gr.,v6<rof. l ., morbus. Yr., maladie, mal. Ger., Krankheit. It., malattia. Sp., enfermedad, mal. Syn.: disorder, affection, complaint, malady. Any departure from, failure in, or perversion of normal physiological action in the material constitution or functional integrity of the living organism, [a, 25.] Acute Bright's d. Lat., morbus Bright i i acutus. Fr., maladie de Bright aigue. Ger., acute Brighfsche Krankheit. It., malattia di Bright acuta. Sp., enfermedad aguda de Bright. See Acute NEPHRITIS. Acute specific d's [Walshe]. The infectious febrile diseases. Add is on's d. Lat., morbus Add is on i i, melasma suprarenale. Fr., maladie d'Add is on. Ger., Add is on's che Krankheit. It., malattia diAddison. Sp.,enfermedaddeAddison(6bronceada). Syn.: bronzed-skin d. A clearly defined, constitutional d. appearing as a chronic, local inflammation of the suprarenal capsules, but really consisting in a " peculiar anaemic condition always tending toward death, which is characterized by an intense development of pigment in the cells of the rete Malpighii and in the epithelium of the mucous membrane of the mouth'" [Averbeck]. The original theory that the inflammatory proce es involving the adrenals with their subsequent degeneration constituted the d. per se has been modified. When there is marked enlargement or the organs and the surrounding inflammation is considerable, the semilunar ganglia and the solar plexus, with the nerves given off by them, are not infrequently found involved. Upon this has been based the a umption that morbid changes in the sympathetic system constitute the initial lesion and fundamental anatomical change upon which the subsequent symptoms are developed. The symptoms develop very gradually, the earlier ones being frequently overlooked. In a well-marked case may be observed wearine , malaise, debility, anaemia, wasting, pearly sclerotics, flabby muscles, and disordered digestion with vomiting, probably sympathetic. Pain is experienced, of more or le severity, in the hypochondria, spine, and joints. The heart impulse becomes weaker and a low anaemic murmur may be heard. The gastro-intestinal disturbances increase and diarrhoea supervenes. An occasional febrile rise may occur, but a low temperature is the rule. The skin discoloration begins at O, no; O2, not; O3, whole; Th, thin; Th, the; U, like oo in too; [s. 593]